Protein & Amino Acids
N-Acetyl L-Tyrosine (NALT)
Also known as: L-Tyrosine · NALT
A catecholamine precursor that replenishes dopamine and norepinephrine under stressful conditions, supporting cognitive performance when these neurotransmitters are depleted.
Effective Dose
500–2000mg / day
per clinical evidence
Evidence Level
Moderate
Protein & Amino Acids
Mechanism
Dopamine and norepinephrine precursor
primary action
Best For
Cognitive performance under stress
Focus, Mood
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is N-Acetyl L-Tyrosine (NALT)?
Tyrosine is the precursor to dopamine, norepinephrine, and adrenaline. Its cognitive benefits are most pronounced under conditions that deplete catecholamines — physical stress, sleep deprivation, cold exposure, and high cognitive load. NALT (N-acetyl L-tyrosine) has greater water solubility but possibly lower bioavailability than free-form L-tyrosine.
How It Works: The Science
Tyrosine → DOPA (via tyrosine hydroxylase) → dopamine → norepinephrine → epinephrine. This rate-limited pathway depends on tyrosine availability. Under stress, catecholamine synthesis accelerates and tyrosine availability becomes limiting. Supplementation prevents the cognitive impairment associated with catecholamine depletion.
Primary Mechanism
Dopamine and norepinephrine precursor
Evidence-Based Benefits
Dosage Guide
Effective Dose
500–2000mg / day
500–2000mg free-form L-tyrosine or 300–1000mg NALT (higher water solubility but equivalent or lower effective dose). Best taken on an empty stomach, 30–60 minutes before the cognitively demanding task or training.
Safety Profile & Side Effects
Well tolerated at recommended doses. Avoid with MAO inhibitors (dangerous catecholamine accumulation). May worsen anxiety in susceptible individuals at high doses. Not recommended with thyroid medication (tyrosine is also a thyroid hormone precursor).
Who Should (and Shouldn't) Take It
Cognitive athletes, shift workers, students, and anyone performing under sleep deprivation or significant stress. Does not reliably improve performance in well-rested, stress-free conditions.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →