Medicinal Mushrooms
Reishi Mushroom
Also known as: Ganoderma lucidum · Lingzhi · Reishi mushroom
The 'mushroom of immortality' in Chinese medicine. Robust evidence for immune modulation, stress reduction, and improved sleep quality. Bitter taste — extract is more practical than raw mushroom.
Effective Dose
1.5–9g dried mushroom or 1–1.5g extract / day
per clinical evidence
Evidence Level
Moderate
Medicinal Mushrooms
Mechanism
Beta-glucan immune modulation, triterpene adaptogenic effects
primary action
Best For
Immune health
Stress, Sleep, Liver protection
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Reishi Mushroom?
Reishi has been used medicinally in East Asia for over 2000 years. Its primary actives — beta-glucan polysaccharides and lanostane-type triterpenes — have distinct and complementary actions. Polysaccharides modulate immunity; triterpenes provide adaptogenic and hepatoprotective effects.
How It Works: The Science
Beta-(1→3)(1→6)-D-glucans activate pattern recognition receptors (Dectin-1, TLR-2) on macrophages, dendritic cells, and NK cells, enhancing immune surveillance. Ganoderic acids (triterpenes) inhibit histamine release and 5-alpha reductase, and modulate HPA axis activity. Reishi also promotes delta-wave sleep via adenosine-related mechanisms.
Primary Mechanism
Beta-glucan immune modulation, triterpene adaptogenic effects
Evidence-Based Benefits
Dosage Guide
Effective Dose
1.5–9g dried mushroom or 1–1.5g extract / day
1.5g concentrated extract (8–10:1) or 9g dried mushroom powder daily. Look for products standardised for beta-glucan content (≥20%) and triterpene content. Avoid products using mycelium on grain as the sole source.
Safety Profile & Side Effects
Generally safe for up to 1 year in clinical trials. Rare liver toxicity reported with powdered reishi (not extracts) — likely due to contaminants. May potentiate anticoagulants (warfarin).
Who Should (and Shouldn't) Take It
Those prioritising immune resilience, sleep quality, and stress management. A good daily mushroom supplement alongside lion's mane for cognitive support.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →