Joint & Connective Tissue
Hyaluronic Acid
Also known as: Hyaluronan · Sodium hyaluronate · HA
The primary lubricant in synovial joint fluid. Oral HA reaches joint tissue via the lymphatic system and reduces joint pain by improving synovial fluid viscosity.
Effective Dose
80–200mg / day
per clinical evidence
Evidence Level
Moderate
Joint & Connective Tissue
Mechanism
Synovial fluid viscosity restoration, cartilage lubrication
primary action
Best For
Joint lubrication
Skin hydration, Eye health
This profile is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications.
What Is Hyaluronic Acid?
Hyaluronic acid is a glycosaminoglycan responsible for the gel-like viscosity of synovial fluid, which lubricates and cushions joints. It is also the primary water-binding molecule in skin. Intra-articular HA injections are established OA treatments; emerging evidence shows oral HA reaches joint tissue via the lymphatic and circulatory systems.
How It Works: The Science
Oral HA is partially absorbed intact (particularly low-molecular-weight HA) and accumulates in synovial fluid and skin dermis via lymphatic distribution. It restores synovial fluid viscosity, reducing friction on articular surfaces. It also stimulates chondrocytes to produce more hyaluronan and proteoglycans. High-molecular-weight HA has superior anti-inflammatory effects; low-molecular-weight improves skin penetration.
Primary Mechanism
Synovial fluid viscosity restoration, cartilage lubrication
Evidence-Based Benefits
Dosage Guide
Effective Dose
80–200mg / day
80–200mg/day oral HA. Skin benefits at 80–120mg; joint benefits at 120–200mg. Average molecular weight formulations balance both applications.
Safety Profile & Side Effects
Excellent safety profile. Derived from rooster combs or microbial fermentation. Not recommended for those with autoimmune conditions — HA is involved in immune signalling and may exacerbate inflammation in susceptible individuals.
Who Should (and Shouldn't) Take It
Athletes with joint discomfort, older adults with OA, and anyone concerned with skin hydration. A good complement to glucosamine, chondroitin, and collagen for comprehensive joint health.
Frequently Asked Questions
Related Ingredients
Medical Disclaimer
Ingredient profiles are for informational purposes only and do not constitute medical advice. Consult a qualified healthcare professional before starting any supplementation, especially if you have pre-existing conditions or take medications. Full disclaimer →